Guide denatured polypeptide chains down the thermodynamic folding funnel into their native, lowest-energy 3D conformation before cellular proteolysis runs out the clock.
1. Manipulate Forces
Tune Hydrophobic Drive to bury gold nonpolar beads into the core, and H-Bond Electrostatics to snap cyan/coral pairs together.
2. Optical Tweezers & Clamps
Left-drag any amino acid directly, or use Chaperone Clamp [2] to tether distant native pairs. Right-drag or empty-drag to orbit camera.
3. Escape Kinetic Traps
Non-native contacts form red jagged Misfold Traps that freeze the chain in local minima. Trigger Chaperone Shock [SPACE] to break them!
4. Reach Native ΔG
Align with the translucent native fold silhouette and form required bonds to lock in the lowest Gibbs Free Energy state.